Maple 
Melanotan 1 peptide Canada: a synthetic linear tridecapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH), also known as afamelanotide. Available from Maple Research Labs at 10mg per vial with 98.82% HPLC-UV verified purity and batch-specific COA.
Product Specifications
- CAS Number: 75921-69-6
- Alternative Name: Afamelanotide, [Nle4, D-Phe7]-alpha-MSH
- Molecular Weight: 1646.85 g/mol
- Purity: 98.82% (HPLC-UV verified, this batch)
- Form: Lyophilized powder
- Quantity: 10mg per vial
Melanotan 1 Peptide Canada Research Summary
Melanotan I (afamelanotide, NDP-alpha-MSH) is a synthetic linear analog of alpha-melanocyte stimulating hormone containing two key modifications: norleucine substitution at position 4 (replacing methionine) and D-phenylalanine substitution at position 7. These modifications were developed by the University of Arizona research group to create a superpotent alpha-MSH analog with enhanced metabolic stability. The melanotan 1 peptide Canada product retains the full 13-amino acid linear structure of alpha-MSH unlike the truncated cyclic structure of Melanotan II.
Melanotan I demonstrates preferential selectivity for the MC1R melanocortin receptor compared to the non-selective profile of Melanotan II. This MC1R selectivity makes it a more targeted research tool for melanocyte biology studies, though it retains measurable activity at other melanocortin receptor subtypes in binding assays.
Mechanism of Action Research
MT-I acts primarily through the MC1R receptor expressed on melanocytes. Receptor activation triggers adenylyl cyclase signaling, elevating intracellular cAMP, which activates protein kinase A (PKA) and subsequently the MITF (melanocyte-inducing transcription factor) pathway. This cascade leads to upregulation of tyrosinase and other enzymes involved in melanin biosynthesis in cell culture models.
The norleucine-4 modification eliminates the methionine residue susceptible to oxidation, while the D-phenylalanine-7 substitution enhances receptor binding affinity by constraining the peptide backbone in a conformation that favors MC1R interaction. Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R.
Research comparing MT-I to MT-II has examined selectivity ratios across melanocortin receptor subtypes, providing insights into structure-activity relationships within the melanocortin peptide family. These comparative studies have been foundational in melanocortin receptor pharmacology research.
Preclinical Study Summary
MT-I has been studied in melanocyte biology, photoprotection research, and erythropoietic protoporphyria models. Published research has examined its effects on melanogenesis, UV-induced DNA damage, and melanocyte proliferation in various experimental systems.
All findings are from preclinical research. No therapeutic claims are made.
References
- Dorr RT, et al. Effects of a superpotent melanotropic peptide on melanogenesis. Peptides. 1988 (PubMed)
Melanotan 1 Peptide Canada Quality Assurance
Verified products of melanotan 1 peptide Canada from Maple Research Labs undergoes independent third-party HPLC analysis confirming purity exceeding 98%+. The active COA reports retention time data, purity percentage, and measured fill accuracy against label claim. Each vial corresponds to the active COA posted on this page and on the Certificates of Analysis page, which is updated when a new batch arrives. Vials do not carry printed lot or batch numbers. The norleucine-4 and D-phenylalanine-7 modifications are verified through sequence analysis on the tested batch.
Storage and Handling
Store lyophilized at -20C. Protect from light.
Shipping
Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking. Temperature-controlled packaging included.
Certificate of Analysis (COA)
| Testing Laboratory | Independent third-party laboratory |
| Report Number | DBAV-MELA1-10-052926 |
| Lot Number | 5666 |
| Purity (HPLC-UV) | 98.82% |
| Content / Fill Accuracy | 9.94mg measured / 10.00mg expected (99.4%) |
| Date Tested | June 9, 2026 |
| Download COA | Download Full COA (PDF) |
For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
Related Research Articles
- Melanotan I vs Melanotan II: Research Comparison
- Research Peptides vs Other Research Compounds
- Certificates of Analysis (COA) Documentation
- Browse All Research Peptides
Frequently Asked Questions
What is the CAS number for Melanotan 1?
The CAS registry number for Melanotan 1 (Afamelanotide) is 75921-69-6. It is a synthetic analog of alpha-MSH.
What purity does Melanotan 1 achieve?
Batch 5666 tested at 98.82% purity by independent HPLC at an independent third-party laboratory.
How does Melanotan 1 differ from Melanotan 2 in research?
Melanotan 1 is a linear 13-amino acid peptide (vs. MT-2 which is a cyclic 7-amino acid peptide). MT-1 is more selective for the MC1R receptor, while MT-2 has broader melanocortin receptor activity in research models.
Related Research Peptides from Maple Research
Researchers may also be interested in Melanotan 2 10MG. All products include third-party purity verification. Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking.
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