Maple Selank research examines a synthetic heptapeptide derived from tuftsin that has been studied in animal models for effects on GABAergic, serotonergic and enkephalinergic signaling and for immunomodulatory activity. This page summarizes its structure, proposed mechanisms and preclinical findings.
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tripeptide extension for enhanced enzymatic stability. Developed alongside Semax at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank represents a distinct pharmacological profile: while Semax primarily modulates the BDNF/TrkB neurotrophic pathway via its ACTH(4-10) origin, Selank influences the GABAergic, serotonergic, and enkephalinergic systems through its tuftsin-derived immunomodulatory core.
Maple Research Labs supplies research-grade Selank to Canadian laboratories, universities, and documented research buyers. Lots are analysed by an independent laboratory, and a certificate of analysis is published for the shipping lot where testing is complete.
For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
Molecular Profile
| Parameter | Value |
|---|---|
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) |
| CAS Number | 129954-34-3 |
| Molecular Formula | C33H57N9O9 |
| Molecular Weight | 751.9 Da |
| Parent Structure | Tuftsin (Thr-Lys-Pro-Arg) + Pro-Gly-Pro extension |
| Purity | Measured by HPLC |
| Storage | -20°C, lyophilized, desiccated, protected from light |
The Pro-Gly-Pro C-terminal extension (shared with Semax) confers resistance to aminopeptidase and carboxypeptidase degradation, extending the biological half-life of the tuftsin core sequence. This same stabilization strategy was applied to both the ACTH(4-10) fragment (producing Semax) and the tuftsin fragment (producing Selank), creating two complementary research tools with distinct primary mechanisms but shared pharmacokinetic engineering.
Primary Research Mechanisms
GABAergic System Modulation
Selank has been shown to influence the GABAergic system in preclinical models. Research indicates that Selank modulates GABA receptor expression and function, with studies demonstrating altered expression of genes encoding GABA-A receptor subunits in the hippocampus following Selank administration. The anxiolytic-like effects observed in behavioral models (elevated plus maze, open field) have been attributed in part to this GABAergic modulation, distinguishing Selank’s mechanism from classical benzodiazepines that directly potentiate GABA-A receptor function.
Enkephalinergic System
Selank influences endogenous opioid peptide metabolism. Research has demonstrated that Selank inhibits enkephalin-degrading enzymes, leading to increased levels of circulating enkephalins. This indirect potentiation of the enkephalinergic system provides a mechanistic basis for the peptide’s observed effects on stress response modulation in animal models, without direct opioid receptor agonism.
Serotonergic System
Preclinical studies have documented Selank’s effects on serotonin metabolism. Selank administration altered serotonin levels and the expression of serotonin-related genes in the hippocampus and frontal cortex of rats. The serotonergic modulation appears to be indirect, mediated through upstream regulatory mechanisms rather than direct receptor binding, which distinguishes Selank from classical serotonergic compounds.
Immunomodulatory Properties
Reflecting its tuftsin heritage, Selank retains immunomodulatory activity. Tuftsin is an endogenous phagocytosis-stimulating peptide, and Selank has been shown to modulate cytokine expression profiles in preclinical models. Research has documented effects on IL-6, TNF-alpha, and other cytokine levels, suggesting a neuroimmune interface that connects Selank’s CNS effects with peripheral immune modulation.
Selank vs. Semax: Complementary Research Tools
| Feature | Selank | Semax |
|---|---|---|
| Parent molecule | Tuftsin (Thr-Lys-Pro-Arg) | ACTH(4-10) (Met-Glu-His-Phe) |
| C-terminal extension | Pro-Gly-Pro | Pro-Gly-Pro |
| Primary CNS mechanism | GABAergic/enkephalinergic modulation | BDNF/TrkB neurotrophic modulation |
| Immunomodulatory | Yes (tuftsin-derived) | Limited |
| Behavioral profile | Anxiolytic-like in preclinical models | Nootropic/cognitive in preclinical models |
| Key research area | Stress response, neuroimmunology | Neuroprotection, cognitive function |
Product Specifications
| Specification | Detail |
|---|---|
| Peptide | Selank (TKPRPGP) |
| CAS Number | 129954-34-3 |
| Purity | Measured by HPLC |
| Form | Lyophilized powder |
| COA | Certificate of analysis where testing is complete included with every order |
| Storage | -20°C, desiccated, protected from light |
| Shipping | Same-day dispatch by 2 PM PT, Mon–Fri |
| Use | For research purposes only |
View Selank product page and COA | How to read a Certificate of Analysis
Frequently Asked Questions
What is Selank and how does it differ from Semax?
Selank and Semax are both synthetic heptapeptides with a shared Pro-Gly-Pro C-terminal extension, but they derive from different parent molecules. Selank is based on the immunomodulatory peptide tuftsin and primarily influences GABAergic and enkephalinergic systems. Semax is based on ACTH(4-10) and primarily modulates the BDNF/TrkB neurotrophic pathway. They serve as complementary research tools for investigating different aspects of CNS function.
Can I purchase Selank for research in Canada?
Yes. Maple Research Labs is a Canadian supplier of research-grade Selank analysed for purity via independent HPLC analysis. All orders include a batch-specific Certificate of Analysis. Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking. Selank is sold exclusively for in-vitro and preclinical research use.
What neurotransmitter systems does Selank modulate?
Research has documented Selank’s influence on three primary neurotransmitter systems: the GABAergic system (modulating GABA-A receptor subunit expression), the enkephalinergic system (inhibiting enkephalin-degrading enzymes to increase endogenous opioid peptide levels), and the serotonergic system (altering serotonin metabolism and related gene expression in the hippocampus and frontal cortex).
How should Selank be stored for research use?
Lyophilized Selank should be stored at -20°C in a desiccated environment protected from light. Reconstituted solutions should be stored at 2-8°C and used within the timeframe appropriate for the research protocol. Avoid repeated freeze-thaw cycles to preserve peptide integrity.
Related Research Resources
- Semax Research Overview — ACTH(4-10) analogue and BDNF modulation
- BPC-157 Research Overview — Cytoprotection and tissue repair
- Semax vs Selank Comparison — Head-to-head research comparison
- Understanding Certificates of Analysis — COA interpretation guide
- All Research Peptides — Complete compound catalog
For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
For peer-reviewed research on this topic, visit PubMed.
Related research resources: product documentation.