Selank

Selank peptide Canada: a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, selank is a research-grade neuropeptide available from Maple Research Labs with greater than 98% HPLC-verified purity and batch-specific COA.

Product Specifications

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (Tuftsin analog with Pro-Gly-Pro extension)
• Base Peptide: Tuftsin (Thr-Lys-Pro-Arg)
• Molecular Weight: Approximately 751 Da
• Purity: >98% (HPLC verified)
• Form: Lyophilized powder
• Quantity: 5mg per vial

Selank Peptide Canada Research Summary

Selank is a synthetic analog of the naturally occurring tetrapeptide tuftsin (Thr-Lys-Pro-Arg), which is derived from the Fc region of immunoglobulin G. The selank peptide Canada research product contains the tuftsin sequence extended with a Pro-Gly-Pro C-terminal tripeptide, a modification designed to increase metabolic stability and extend biological half-life compared to native tuftsin.

Tuftsin was first described by Najjar and Nishioka in 1970 as a phagocytosis-stimulating peptide. Selank extends this research by incorporating structural modifications that resist enzymatic degradation while potentially retaining and expanding the biological activities of the parent tetrapeptide.

Mechanism of Action Research

Published research has examined selank’s interactions with several neurochemical systems. Studies in rodent models have reported modulation of monoamine neurotransmitter levels, with published data indicating effects on serotonin metabolism and BDNF (brain-derived neurotrophic factor) expression in specific brain regions.

The Pro-Gly-Pro extension on the tuftsin sequence has been studied for its contribution to selank’s pharmacological profile. Research suggests this modification not only enhances metabolic stability but may independently modulate inflammatory signaling through effects on cytokine expression patterns observed in cell culture and animal models.

Gene expression studies using microarray analysis have reported that selank modulates expression of genes involved in GABAergic neurotransmission, inflammatory response regulation, and neurotrophic factor signaling. Published transcriptomic data from rodent hippocampal tissue has identified over 30 genes significantly modulated by selank administration.

Preclinical Study Summary

Selank has been investigated in behavioral pharmacology models including elevated plus maze, open field, and forced swim paradigms in rodents. Additional research has examined its immunomodulatory properties, including effects on natural killer cell activity, phagocyte function, and cytokine expression in immune cell cultures. The peptide’s dual neuropeptide-immunomodulatory research profile distinguishes it within the tuftsin analog class.

All findings are from preclinical animal model and in vitro studies. No therapeutic claims are made.

References

• Seredenin SB, et al. Anxiolytic effect of selank and its metabolites. Bull Exp Biol Med. 2006 (PubMed)

Selank Peptide Canada Quality Assurance

Every batch of selank peptide Canada from Maple Research Labs undergoes independent third-party HPLC analysis confirming purity exceeding 98%. Each order includes a batch-specific COA with retention time data, purity percentage, and mass spectrometry identity confirmation. The tuftsin-derived heptapeptide structure requires sequence-specific verification, confirmed for every production batch shipped to Canadian research facilities.

Storage and Handling

Store lyophilized at -20C. Reconstituted at 2-8C, use within 14 days due to shorter stability profile. Protect from light.

Shipping

Ships same-day from our Canadian facility. Temperature-controlled packaging included.

Certificate of Analysis (COA)

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Related Research Articles

• Semax vs Selank: Neuropeptide Research Comparison
• Research Peptides vs Other Research Compounds
• Certificates of Analysis (COA) Documentation
• Browse All Research Peptides

Frequently Asked Questions

What is the CAS number for Selank?

The CAS registry number for Selank is 129954-34-3. It is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin.

What purity does Selank achieve?

Batch MRL-SEL-0326 tested at 99.2% purity by HPLC at Janoshik Analytical with publicly verifiable COA.

What research areas involve Selank?

Selank has been studied for anxiolytic and nootropic properties in animal models, with research focusing on GABAergic system modulation and BDNF expression.