PACAP Peptide Research: PAC1 Receptor Pharmacology, Neuroprotection Mechanisms, and Preclinical Evidence
PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is a 38-amino acid neuropeptide with potent neuroprotective activity mediated through PAC1, VPAC1, and VPAC2 receptors. This review covers receptor pharmacology, cAMP-PKA-CREB signaling, and preclinical data from ischemia, retinal, and cardiovascular models.
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