Peptide Deep Dives

RXFP1 is a GPCR that activates by relieving ectodomain autoinhibition. Relaxin-2 drives MMP upregulation via ERK and nitric oxide-cGMP signalling, yet the 6,545-subject RELAX-AHF-2 trial returned a null result.

A research overview of exendin-4, the DPP-4-resistant GLP-1 receptor agonist isolated from Gila monster venom, covering receptor pharmacology and preclinical animal-model evidence.

A research overview of irisin, the FNDC5-derived myokine that drives brown-fat-like browning of white adipose tissue, summarizing preclinical mechanism, bone and neural findings, and the measurement controversy. For research purposes only.

Cholecystokinin (CCK) is a gut-brain peptide that signals meal-related satiety through the CCK1 receptor on vagal afferent neurons, and it

Oxyntomodulin is the endogenous 37 amino acid dual GLP-1R/GCGR agonist that established the dual agonist thesis. Mechanism, biased signaling, and preclinical evidence.

Teriparatide peptide research focuses on rhPTH(1-34), the biologically active N-terminal 34 amino acids of human parathyroid hormone and the prototypical

Teriparatide is recombinant human parathyroid hormone fragment PTH(1-34), a 34 amino acid peptide that acts as a potent bone anabolic

A research review of setmelanotide, the selective MC4R agonist peptide: receptor binding pharmacology, leptin-melanocortin signaling mechanism, and published study data.

PYY 3-36 is a truncated form of the gut-derived hormone peptide YY that acts with high selectivity at the Y2

Mechano growth factor (MGF) is a splice variant of insulin-like growth factor 1, formally designated IGF-1Ec, that muscle tissue produces