AOD-9604

AOD-9604 is a synthetic analogue of the C-terminal 176-191 fragment of human growth hormone with an added N-terminal tyrosine residue. Preclinical work characterises it as acting on lipid metabolism through beta-3 adrenergic pathways without the receptor-mediated growth signalling attributed to the full-length hormone. For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Product Specifications

• CAS Number: 221231-10-3
• Molecular Formula: C₇₈H₁₂₃N₂₁O₂₃S₂
• Molecular Weight: 1815.08 g/mol
• Purity: measured by HPLC-UV, see the certificate of analysis for this compound
• Form: Lyophilized powder
• Quantity: 5mg per vial

Research Summary

AOD-9604 is a synthetic peptide corresponding to the C-terminal fragment (amino acids 176-191) of human growth hormone, with an additional tyrosine residue at the N-terminus. This modified fragment has been investigated in preclinical research for its effects on lipid metabolism signaling pathways independent of the somatotropic (growth-promoting) actions associated with full-length growth hormone. In-vitro studies indicate that AOD-9604 may influence lipolytic signaling cascades and inhibit lipogenic enzyme activity in adipocyte cell culture models.

In animal models, AOD-9604 has been studied for its effects on adipose tissue metabolism, including fat oxidation markers and lipogenesis-related gene expression in rodent models. Preclinical research has examined the peptide’s influence on beta-3 adrenergic receptor-mediated signaling and its observed effects on adipocyte differentiation pathways. Notably, studies in animal models have investigated AOD-9604 for its lack of observed effects on IGF-1 levels, blood glucose, or insulin sensitivity markers, distinguishing it from full-length GH in preclinical metabolic research.

Researchers have also investigated AOD-9604 for its effects on chondrocyte proliferation and proteoglycan synthesis in cartilage tissue models. The compound serves as a useful tool for studying GH fragment biology, adipocyte signaling, and the dissociation of lipolytic and somatotropic pathways in controlled research settings.

Storage

Store lyophilized peptide at -20°C. Reconstituted solution should be stored at 2-8°C and used within 28 days. Avoid repeated freeze-thaw cycles.

Shipping

Ships same-day from our Canadian facility. All orders include temperature-controlled packaging.

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Related Research Reading

Extended mechanistic coverage is available in AOD-9604 hGH fragment 176-191 lipolysis mechanisms. Third-party analytical documentation is published on the Certificates of Analysis page, and the full research compound catalogue lists currently available compounds.

Maple Research Labs supplies AOD-9604 to research laboratories across Canada for preclinical study applications.