Melanotan 1 10MG

Melanotan 1 peptide Canada: a synthetic linear tridecapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH), also known as afamelanotide. Available from Maple Research Labs at 10mg per vial with greater than 99%+ HPLC-verified purity and batch-specific COA.

Product Specifications

• CAS Number: 75921-69-6
• Alternative Name: Afamelanotide, [Nle4, D-Phe7]-alpha-MSH
• Molecular Weight: 1646.85 g/mol
• Purity: >99%+ (HPLC verified)
• Form: Lyophilized powder
• Quantity: 10mg per vial

Melanotan 1 Peptide Canada Research Summary

Melanotan I (afamelanotide, NDP-alpha-MSH) is a synthetic linear analog of alpha-melanocyte stimulating hormone containing two key modifications: norleucine substitution at position 4 (replacing methionine) and D-phenylalanine substitution at position 7. These modifications were developed by the University of Arizona research group to create a superpotent alpha-MSH analog with enhanced metabolic stability. The melanotan 1 peptide Canada product retains the full 13-amino acid linear structure of alpha-MSH unlike the truncated cyclic structure of Melanotan II.

Melanotan I demonstrates preferential selectivity for the MC1R melanocortin receptor compared to the non-selective profile of Melanotan II. This MC1R selectivity makes it a more targeted research tool for melanocyte biology studies, though it retains measurable activity at other melanocortin receptor subtypes in binding assays.

Mechanism of Action Research

MT-I acts primarily through the MC1R receptor expressed on melanocytes. Receptor activation triggers adenylyl cyclase signaling, elevating intracellular cAMP, which activates protein kinase A (PKA) and subsequently the MITF (melanocyte-inducing transcription factor) pathway. This cascade leads to upregulation of tyrosinase and other enzymes involved in melanin biosynthesis in cell culture models.

The norleucine-4 modification eliminates the methionine residue susceptible to oxidation, while the D-phenylalanine-7 substitution enhances receptor binding affinity by constraining the peptide backbone in a conformation that favors MC1R interaction. Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R.

Research comparing MT-I to MT-II has examined selectivity ratios across melanocortin receptor subtypes, providing insights into structure-activity relationships within the melanocortin peptide family. These comparative studies have been foundational in melanocortin receptor pharmacology research.

Preclinical Study Summary

MT-I has been studied in melanocyte biology, photoprotection research, and erythropoietic protoporphyria models. Published research has examined its effects on melanogenesis, UV-induced DNA damage, and melanocyte proliferation in various experimental systems.

All findings are from preclinical research. No therapeutic claims are made.

References

• Dorr RT, et al. Effects of a superpotent melanotropic peptide on melanogenesis. Peptides. 1988 (PubMed)

Melanotan 1 Peptide Canada Quality Assurance

Verified products of melanotan 1 peptide Canada from Maple Research Labs undergoes independent third-party HPLC analysis confirming purity exceeding 99%+. Each order includes a batch-specific COA with retention time data, purity percentage, and mass spectrometry confirmation. The norleucine-4 and D-phenylalanine-7 modifications are verified through sequence analysis on every production batch.

Storage and Handling

Store lyophilized at -20C. Reconstituted at 2-8C, use within 28 days. Protect from light.

Shipping

Ships same-day from our Canadian facility. Temperature-controlled packaging included.

Certificate of Analysis (COA)

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Related Research Articles

• Melanotan I vs Melanotan II: Research Comparison
• Research Peptides vs Other Research Compounds
• Certificates of Analysis (COA) Documentation
• Browse All Research Peptides

Frequently Asked Questions

What is the CAS number for Melanotan 1?

The CAS registry number for Melanotan 1 (Afamelanotide) is 75921-69-6. It is a synthetic analog of alpha-MSH.

What purity does Melanotan 1 achieve?

Batch 5666 tested at 98.82% purity by independent HPLC at Testides Analytical.

How does Melanotan 1 differ from Melanotan 2 in research?

Melanotan 1 is a linear 13-amino acid peptide (vs. MT-2 which is a cyclic 7-amino acid peptide). MT-1 is more selective for the MC1R receptor, while MT-2 has broader melanocortin receptor activity in research models.

Related Research Peptides from Maple Research

Researchers may also be interested in Melanotan 2 10MG, and bacteriostatic water. All products are shipped same-day from Canada with third-party purity verification.