Maple 
Melanotan 2 peptide Canada: a synthetic cyclic lactam analog of alpha-melanocyte stimulating hormone (alpha-MSH). This non-selective melanocortin receptor agonist is available from Maple Research Labs at 10mg per vial with 99.52% HPLC-UV verified purity and batch-specific COA.
Product Specifications
- CAS Number: 121062-08-6
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Molecular Weight: 1024.18 g/mol
- Tested 10mg sample: 99.52% HPLC-UV relative-area purity (report DBAV-MELA-10-052926). The linked report does not report a separate cyclization or structural-confirmation assay.
- Form: Lyophilized powder
- Quantity: 10mg per vial
Melanotan 2 Peptide Canada Research Summary
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH) developed at the University of Arizona by Dr. Victor Hruby and colleagues. Unlike the linear 13-amino acid alpha-MSH, melanotan 2 peptide Canada features a cyclic lactam structure with a D-phenylalanine substitution that confers enhanced receptor binding potency and metabolic stability.
MT-II acts as a non-selective agonist at melanocortin receptors MC1R through MC5R, with research documenting activity at all five receptor subtypes. This broad receptor profile distinguishes it from more selective melanocortin agonists and has made it a widely used pharmacological tool in melanocortin biology research.
Mechanism of Action Research
The melanocortin receptor system comprises five G protein-coupled receptors (MC1R through MC5R) with distinct tissue distribution and biological functions. MT-II research has focused primarily on its interactions with MC1R (melanocyte regulation), MC3R, and MC4R receptor pharmacology in preclinical models.
Published binding studies have characterized MT-II’s affinity profile across melanocortin receptor subtypes. The cyclic lactam structure constrains the peptide’s conformation, positioning the core pharmacophore (His-D-Phe-Arg-Trp) for optimal receptor interaction. Research has compared MT-II binding kinetics to linear alpha-MSH and to the more selective analog Melanotan I (afamelanotide).
In vitro studies have examined MT-II’s effects on melanogenesis in melanocyte cell cultures, including cAMP signaling, tyrosinase activity, and melanin production. MC4R-related research has investigated the peptide’s effects on hypothalamic signaling pathways in rodent brain slice preparations and in vivo administration studies.
Preclinical Study Summary
MT-II has been extensively studied across multiple research domains since its synthesis in the early 1990s. Published research spans melanocyte biology and melanocortin receptor pharmacology in cell and animal models. The compound’s non-selective melanocortin agonism has made it a foundational research tool, though its broad receptor profile is a limitation for studies requiring receptor-specific effects.
All findings are from preclinical and in vitro research. No therapeutic claims are made.
References
Melanotan 2 Peptide Canada Quality Assurance
Third-party certificates of analysis for tested lots are published on our COA page. Read the applicable report for its tested compound, size, method and results. Read the applicable report for any reported retention time, method-specific relative-area purity and separately measured content. These results apply to its tested sample. Published sample reports alone do not establish the lot or analysis of a specific supplied vial. Vials do not carry printed lot or batch numbers. Review the individual report for the analyses actually performed. HPLC-UV purity alone does not establish sequence, cyclization, oxidation state or shipping-unit consistency.
Storage and Handling
Store lyophilized at -20C. Protect from light.
Shipping
Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking. Temperature-controlled packaging included.
Certificate of Analysis (COA)
| Testing Laboratory | Independent third-party laboratory |
| Report Number | DBAV-MELA-10-052926 |
| Lot Number | 5766 |
| Purity (HPLC-UV) | 99.52% |
| Content / Fill Accuracy | 10.52mg measured / 10.00mg expected (105.2%) |
| Date Tested | June 9, 2026 |
| Download COA | Download Full COA (PDF) |
For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
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- Certificates of Analysis (COA) Documentation
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Frequently Asked Questions
What is the CAS number for Melanotan 2?
The CAS registry number for Melanotan 2 (MT-II) is 121062-08-6. It is a synthetic analog of alpha-melanocyte-stimulating hormone.
How is Melanotan 2 purity verified?
Independent HPLC analysis by an independent third-party laboratory. The linked report lists sample identifier 5766 and a reported purity of 99.52%; consult that report for its tested size and analytical scope. This does not by itself establish the lot currently shipping.
How should Melanotan 2 be stored?
Store lyophilized at -20C, protected from light. MT-2 contains methionine and is susceptible to oxidation.
Related Research Peptides from Maple Research
Researchers may also be interested in Melanotan 1 10MG. See each product’s available analytical documentation and tested-sample results in the COA index. Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking.
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