Maple 
Product Specifications
- CAS Number: 53-84-9
- Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
- Molecular Weight: 663.43 g/mol
- Purity: 99.9% (HPLC-MS/MS, lot 082126)
- Form: Lyophilized powder
- Quantity: 1000mg per vial
Research Summary
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells that functions as a critical electron carrier in metabolic redox reactions. In-vitro studies have extensively characterized its role as a substrate in over 500 enzymatic reactions, including those catalyzed by the sirtuin family of NAD+-dependent deacetylases (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38/CD157 ectoenzymes. These enzyme families have been investigated for their roles in DNA repair signaling, epigenetic regulation, and cellular stress response pathways in cell culture models.
In animal models, NAD+ metabolism has been studied in the context of age-related decline in intracellular NAD+ levels and its effects on mitochondrial function, genomic stability, and metabolic pathway regulation. Preclinical research has examined the compound’s influence on sirtuin-mediated deacetylation of transcription factors including PGC-1alpha, FOXO, and p53 in rodent tissue models. Researchers have also investigated NAD+ in relation to circadian rhythm signaling, where it serves as a substrate for the SIRT1-mediated regulation of CLOCK-BMAL1 transcriptional activity.
NAD+ serves as a fundamental research tool in cellular metabolism, aging biology, and enzymology studies. Its central role in energy metabolism, redox biology, and cell signaling makes it indispensable for in-vitro investigations across bioenergetics, epigenetics, and related research disciplines.
Storage
Store lyophilized peptide at -20°C. Reconstituted solution should be stored at 2-8°C and used within 28 days. Avoid repeated freeze-thaw cycles.
Shipping
Ships same-day from our Canadian facility. All orders include temperature-controlled packaging.
Certificate of Analysis (COA)
A sample from the current NAD+ lot (082126) was analyzed by SideChain Analytics, an independent laboratory in Mississauga, Ontario. It measured 99.9% chromatographic purity by HPLC-MS/MS, with identity confirmed against a reference standard and 1211.63 mg net content against the 1000 mg label.
| Testing Laboratory | SideChain Analytics, Mississauga, Ontario (independent third-party laboratory) |
| Report Number | COA-2026-SC-01771 |
| Lot Number | 082126 |
| Method | HPLC-MS/MS (Agilent 1290 Infinity II with 6495 triple quadrupole) |
| Identity | NAD+, principal component confirmed against reference standard |
| Purity (HPLC-MS/MS) | 99.9% |
| Net Content / Fill Accuracy | 1211.63mg measured / 1000mg label (121.2%) |
| Date Analyzed | September 1, 2026 |
| Download COA | Download Full COA (PDF) |
| Verify at the Lab | Open the laboratory’s verification page for this report, or enter the report number at sidechainanalytics.com |
Results are for the sample the laboratory received, reported as measured. The original PDF is also served by the laboratory from its own verification page.
For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
Related Research Articles
Learn more about this compound through our peer-reviewed research summaries:
- NAD+ vs Glutathione: Cellular Research Comparison
- NAD+ and Longevity Peptides Research
- NAD+ vs SS-31: Mitochondrial Research Comparison
- 5-Amino-1MQ: NNMT Inhibition and NAD+ Rescue
- Certificates of Analysis and Documentation
Related catalogue compounds: SS-31, MOTS-c and 5-Amino-1MQ.
Maple Research Labs supplies NAD+ to research laboratories across Canada for in-vitro study applications.
15% off your first order
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