Melanotan 2 10MG

Melanotan 2 peptide Canada: a synthetic cyclic lactam analog of alpha-melanocyte stimulating hormone (alpha-MSH). This non-selective melanocortin receptor agonist is available from Maple Research Labs at 10mg per vial with greater than 98% HPLC-verified purity and batch-specific COA.

Product Specifications

• CAS Number: 121062-08-6
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• Molecular Weight: 1024.18 g/mol
• Purity: >98% (HPLC verified)
• Form: Lyophilized powder
• Quantity: 10mg per vial

Melanotan 2 Peptide Canada Research Summary

Melanotan II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH) developed at the University of Arizona by Dr. Victor Hruby and colleagues. Unlike the linear 13-amino acid alpha-MSH, melanotan 2 peptide Canada features a cyclic lactam structure with a D-phenylalanine substitution that confers enhanced receptor binding potency and metabolic stability.

MT-II acts as a non-selective agonist at melanocortin receptors MC1R through MC5R, with research documenting activity at all five receptor subtypes. This broad receptor profile distinguishes it from more selective melanocortin agonists and has made it a widely used pharmacological tool in melanocortin biology research.

Mechanism of Action Research

The melanocortin receptor system comprises five G protein-coupled receptors (MC1R through MC5R) with distinct tissue distribution and biological functions. MT-II research has focused primarily on its interactions with MC1R (melanocyte regulation), MC3R (energy homeostasis), and MC4R (appetite and autonomic function) in preclinical models.

Published binding studies have characterized MT-II’s affinity profile across melanocortin receptor subtypes. The cyclic lactam structure constrains the peptide’s conformation, positioning the core pharmacophore (His-D-Phe-Arg-Trp) for optimal receptor interaction. Research has compared MT-II binding kinetics to linear alpha-MSH and to the more selective analog Melanotan I (afamelanotide).

In vitro studies have examined MT-II’s effects on melanogenesis in melanocyte cell cultures, including dose-response relationships for cAMP signaling, tyrosinase activity, and melanin production. MC4R-related research has investigated the peptide’s effects on hypothalamic signaling pathways in rodent brain slice preparations and in vivo administration studies.

Preclinical Study Summary

MT-II has been extensively studied across multiple research domains since its synthesis in the early 1990s. Published research spans melanocyte biology, appetite regulation, energy homeostasis, and reproductive physiology in animal models. The compound’s non-selective melanocortin agonism has made it a foundational research tool, though its broad receptor profile is a limitation for studies requiring receptor-specific effects.

All findings are from preclinical and in vitro research. No therapeutic claims are made.

References

• Hruby VJ, et al. Design of novel cyclic alpha-MSH analogues with selective melanocortin receptor binding. J Med Chem. 1995 (PubMed)

Melanotan 2 Peptide Canada Quality Assurance

Every batch of melanotan 2 peptide Canada from Maple Research Labs undergoes independent third-party HPLC analysis confirming purity exceeding 98%. Each order includes a batch-specific COA documenting retention time data, purity percentage, and mass spectrometry identity verification. The cyclic lactam structure of MT-II requires specific analytical methods to verify correct cyclization, which our third-party laboratory confirms on every production batch.

Storage and Handling

Store lyophilized at -20C. Reconstituted at 2-8C, use within 30 days. Protect from light.

Shipping

Ships same-day from our Canadian facility. Temperature-controlled packaging included.

Certificate of Analysis (COA)

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

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Frequently Asked Questions

What is the CAS number for Melanotan 2?

The CAS registry number for Melanotan 2 (MT-II) is 121062-08-6. It is a synthetic analog of alpha-melanocyte-stimulating hormone.

How is Melanotan 2 purity verified?

Independent HPLC analysis by Janoshik Analytical. Current batch MRL-MT2-0326 tested at 99.0% purity with publicly verifiable COA.

How should Melanotan 2 be stored?

Store lyophilized at -20C, protected from light. MT-2 contains methionine and is susceptible to oxidation. Reconstituted solution: 2-8C, use within 21 days.