PT-141

PT-141 peptide Canada: a synthetic melanocortin receptor agonist also known as bremelanotide, derived from the Melanotan II structure. Available from Maple Research Labs with greater than 98% HPLC-verified purity and batch-specific COA. Currently out of stock.

Product Specifications

• CAS Number: 189691-06-3
• Alternative Name: Bremelanotide
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molecular Weight: 1025.18 g/mol
• Purity: >98% (HPLC verified)
• Form: Lyophilized powder

PT-141 Peptide Canada Research Summary

PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist structurally derived from Melanotan II. The PT-141 peptide Canada research product differs from MT-II by the replacement of the C-terminal amide with a hydroxyl group, resulting in a free carboxylic acid terminus. This seemingly minor structural change significantly alters the compound’s receptor selectivity profile compared to its parent molecule.

PT-141 was discovered during research into Melanotan II metabolites, when investigators observed that the active metabolite retained certain melanocortin receptor activities while losing others. This observation led to dedicated research into PT-141 as a distinct pharmacological compound with a different receptor activation profile than its precursor.

Mechanism of Action Research

PT-141 acts as an agonist at melanocortin receptors, with published research focusing primarily on MC3R and MC4R interactions. Unlike MT-II, which demonstrates broad activity across all five melanocortin receptor subtypes, PT-141’s modified C-terminus results in a narrower receptor activation profile that has been characterized in binding and functional assays.

Research has examined PT-141’s effects through central nervous system melanocortin pathways, particularly MC4R-mediated signaling in hypothalamic nuclei. Published studies in rodent models have investigated downstream effects of MC4R activation, including oxytocin release from paraventricular nucleus neurons and modulation of autonomic nervous system activity.

Comparative pharmacological studies have characterized PT-141’s binding affinity and functional potency relative to MT-II, alpha-MSH, and other melanocortin agonists at each receptor subtype. These structure-activity relationship studies have contributed to the understanding of how C-terminal modifications alter melanocortin receptor selectivity.

Preclinical Study Summary

PT-141 has been investigated in multiple preclinical research contexts examining melanocortin receptor pharmacology, autonomic nervous system regulation, and hypothalamic signaling pathways. Published studies span receptor binding assays, in vivo rodent behavioral models, and mechanistic investigations into MC3R/MC4R downstream signaling cascades.

All findings are from preclinical research. No therapeutic claims are made.

References

• Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 (PubMed)

PT-141 Peptide Canada Quality Assurance

Every batch of PT-141 peptide Canada from Maple Research Labs undergoes independent third-party HPLC analysis confirming purity exceeding 98%. Each order includes a batch-specific COA with retention time data, purity percentage, and mass spectrometry identity confirmation. The cyclic lactam structure of bremelanotide requires specific analytical verification of correct cyclization, confirmed on every production batch.

Storage and Handling

Store lyophilized at -20C. Reconstituted at 2-8C, use within 30 days. Protect from light.

Shipping

Ships same-day from our Canadian facility when in stock. Temperature-controlled packaging included.

Related Research Articles

Learn more about this compound through our peer-reviewed research summaries:

• Melanotan I vs Melanotan II: Melanocortin Research Comparison
• Research Peptides vs Other Research Compounds
• Certificates of Analysis (COA) Documentation
• Browse All Research Peptides

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Frequently Asked Questions

What is the CAS number for PT-141?

The CAS registry number for PT-141 (Bremelanotide) is 32780-32-8. It is a synthetic melanocortin receptor agonist.

What is PT-141 purity?

Batch MRL-PT1-0326 tested at 98.7% purity by independent HPLC at Janoshik Analytical.

How should PT-141 be stored?

Lyophilized: -20C for 18+ months. Reconstituted: 2-8C for up to 21 days in bacteriostatic water.