PT-141

PT-141 peptide Canada from Maple Research Labs provides 10mg of Bremelanotide research peptide with third party HPLC-UV purity analysis, with a certificate of analysis published when testing completes.

PT-141 peptide Canada: a synthetic melanocortin receptor agonist also known as bremelanotide, derived from the Melanotan II structure. Available from Maple Research Labs with third party HPLC-UV purity analysis, with a certificate of analysis published when testing completes. Currently out of stock.

Product Specifications

• CAS Number: 189691-06-3
• Alternative Name: Bremelanotide
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molecular Weight: 1025.18 g/mol
• Purity: measured by HPLC-UV, see the certificate of analysis for this compound
• Form: Lyophilized powder

PT-141 Peptide Canada Research Summary

PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist structurally derived from Melanotan II. The PT-141 peptide Canada research product differs from MT-II by the replacement of the C-terminal amide with a hydroxyl group, resulting in a free carboxylic acid terminus. This seemingly minor structural change significantly alters the compound’s receptor selectivity profile compared to its parent molecule.

PT-141 was discovered during research into Melanotan II metabolites, when investigators observed that the active metabolite retained certain melanocortin receptor activities while losing others. This observation led to dedicated research into PT-141 as a distinct pharmacological compound with a different receptor activation profile than its precursor.

Mechanism of Action Research

PT-141 acts as an agonist at melanocortin receptors, with published research focusing primarily on MC3R and MC4R interactions. Unlike MT-II, which demonstrates broad activity across all five melanocortin receptor subtypes, PT-141’s modified C-terminus results in a narrower receptor activation profile that has been characterized in binding and functional assays.

Research has examined PT-141’s effects through central nervous system melanocortin pathways, particularly MC4R-mediated signaling in hypothalamic nuclei. Published studies in rodent models have investigated downstream effects of MC4R activation, including oxytocin release from paraventricular nucleus neurons and modulation of autonomic nervous system activity.

Comparative pharmacological studies have characterized PT-141’s binding affinity and functional potency relative to MT-II, alpha-MSH, and other melanocortin agonists at each receptor subtype. These structure-activity relationship studies have contributed to the understanding of how C-terminal modifications alter melanocortin receptor selectivity.

Preclinical Study Summary

PT-141 has been investigated in multiple preclinical research contexts examining melanocortin receptor pharmacology, autonomic nervous system regulation, and hypothalamic signaling pathways. Published studies span receptor binding assays, in vivo rodent behavioral models, and mechanistic investigations into MC3R/MC4R downstream signaling cascades.

All findings are from preclinical research. No therapeutic claims are made.

References

• Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 (PubMed)

PT-141 Peptide Canada Quality Assurance

This product description does not establish analytical results for current shipping stock. Consult available sample-specific documentation. Published sample reports alone do not establish the lot or analysis of a specific supplied vial. Vials do not carry printed lot or batch numbers. No public report is linked in this product description. This does not establish whether other documentation or testing exists. Do not infer structural confirmation unless the applicable report explicitly includes it.

Storage and Handling

Store lyophilized at -20C. Protect from light.

Shipping

Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking. This applies to in-stock items. Temperature-controlled packaging included.

Related Research Articles

Learn more about this compound through our peer-reviewed research summaries:

• Melanotan I vs Melanotan II: Melanocortin Research Comparison
• Research Peptides vs Other Research Compounds
• Certificates of Analysis (COA) Documentation
• Browse All Research Peptides

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Frequently Asked Questions

What is the CAS number for PT-141?

The CAS registry number for PT-141 (Bremelanotide) is 189691-06-3. It is a synthetic melanocortin receptor agonist.

What is PT-141 purity?

This description does not establish a current-stock purity result, testing timeline or report-publication date. Review available analytical documentation for the tested sample and method.

How should PT-141 be stored?

Lyophilized: -20C for 18+ months.

Related Research Peptides from Maple Research

Researchers may also be interested in Melanotan 2 10MG, Melanotan 1 10MG. See each product’s available analytical documentation and tested-sample results in the COA index. Orders placed by 2 PM PT (Mon–Fri) ship the same business day, from BC with tracking.