IGF-1 LR3 vs IGF-1 DES: Research Comparison
A comprehensive comparison of two modified IGF-1 variants with distinct pharmacokinetic profiles. Understanding the structural and functional differences for growth factor research.
Quick Comparison
| Category | IGF-1 LR3 | IGF-1 DES |
|---|---|---|
| Compound Type | Modified IGF-1 variant | Truncated IGF-1 variant |
| Amino Acid Length | 83 amino acids | 67 amino acids |
| Key Modification | 13 amino acid N-terminal extension | Truncated N-terminus (des 1-3) |
| IGF Binding Protein Affinity | Significantly reduced | Significantly reduced |
| Research Half-Life | ~20-30 hours (extended) | ~20-30 minutes (short) |
| Primary Research Focus | Extended action studies | Acute signaling studies |
| Purity Standard | ≥98% HPLC verified | ≥98% HPLC verified |
| Documentation | Full COA with MS confirmation | Full COA with MS confirmation |
What Is IGF-1 LR3?
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an 83-amino acid synthetic analogue of native IGF-1. The "LR3" designation refers to a 13-amino acid extension at the N-terminus and an arginine substitution for glutamic acid at position 3. These modifications significantly reduce binding to IGF binding proteins (IGFBPs).
The reduced IGFBP affinity results in a dramatically extended half-life compared to native IGF-1, making IGF-1 LR3 valuable for laboratory research involving:
- Extended IGF-1 receptor activation studies
- Prolonged growth factor signaling pathway research
- IGFBP interaction and modulation studies
- Comparative studies with native IGF-1
For Canadian researchers studying growth factor pathways, IGF-1 LR3 provides a tool for understanding sustained receptor activation without the rapid clearance seen with native IGF-1. All products include comprehensive COA documentation.
What Is IGF-1 DES?
IGF-1 DES (Des(1-3) IGF-1) is a 67-amino acid truncated form of IGF-1 with the first three amino acids (Gly-Pro-Glu) removed from the N-terminus. This modification also dramatically reduces binding to IGF binding proteins, but results in a much shorter half-life compared to IGF-1 LR3.
The truncated structure provides distinct research advantages:
- Rapid IGF-1 receptor activation studies
- Acute signaling pathway research
- Precise timing control in experimental models
- Short-duration receptor stimulation studies
IGF-1 DES is particularly useful for researchers needing precise temporal control over IGF-1 receptor stimulation. The short half-life allows for acute pulse experiments and time-course studies in laboratory settings.
Mechanism of Action Comparison
IGF-1 LR3
- •Reduced IGFBP-1, -2, -3 binding affinity
- •Extended circulating half-life (~20-30 hours)
- •Sustained IGF-1 receptor activation
- •Full receptor binding affinity maintained
IGF-1 DES
- •Reduced IGFBP binding via truncation
- •Short half-life (~20-30 minutes)
- •Rapid, acute receptor activation
- •Enhanced receptor binding potency reported
Research Applications Comparison
The choice between IGF-1 LR3 and IGF-1 DES depends on the specific temporal requirements of your research. Each variant excels in different experimental contexts.
IGF-1 LR3 Applications
- • Chronic exposure studies
- • Extended pathway activation research
- • IGFBP modulation investigations
- • Long-term cell culture experiments
- • Sustained signaling cascade studies
IGF-1 DES Applications
- • Acute stimulation experiments
- • Time-course signaling studies
- • Pulse-chase experiments
- • Rapid receptor activation research
- • Localized signaling studies
Stability & Handling Comparison
Storage Requirements
Both variants require careful storage for optimal stability:
- • Lyophilized: Store at -20°C to -80°C
- • Reconstituted: Store at 2-8°C, use within 7 days
- • Avoid repeated freeze-thaw cycles
- • Protect from light and oxidation
Handling Considerations
Key differences in experimental handling:
- • IGF-1 LR3: Single application protocols
- • IGF-1 DES: May require repeated applications
- • Both: Use sterile technique
- • Both: Avoid acidic pH conditions
Summary: Researcher Selection Framework
Choose IGF-1 LR3 When:
- ✓ Studying prolonged growth factor effects
- ✓ Requiring sustained receptor activation
- ✓ Conducting chronic exposure studies
- ✓ Minimizing dosing frequency in protocols
Choose IGF-1 DES When:
- ✓ Studying acute signaling responses
- ✓ Requiring precise temporal control
- ✓ Conducting pulse experiments
- ✓ Investigating rapid receptor dynamics
Both IGF-1 variants are available with ≥98% purity and comprehensive COA documentation. Explore our research peptides catalog or view Ipamorelin vs CJC-1295 for related growth pathway research compounds.
Why Documentation & Testing Matter
In research settings, the reliability of results depends entirely on the quality and consistency of materials used. Third-party verification provides an objective baseline for researchers to trust their experimental inputs.
Third-Party Testing
Independent laboratory verification ensures unbiased purity and identity confirmation.
Batch Consistency
Each production batch is individually tested and documented for reproducibility.
≥98% Purity Standard
HPLC and mass spectrometry verification for research-grade quality assurance.
Transparent COAs
Complete Certificates of Analysis available for every product and batch.
Research-Grade Standards from Maple Research Labs
We're committed to providing researchers with consistently high-quality compounds, transparent documentation, and reliable service across Canada.
Canadian-Based Fulfillment
Fast domestic shipping from within Canada, reducing transit times and customs delays.
Independent Lab Testing
Every batch verified by third-party laboratories for purity and identity confirmation.
Research-Only Compliance
Clear labeling and documentation designed for legitimate research applications.
Consistent Quality Standards
Rigorous QC protocols ensure batch-to-batch consistency for reliable research outcomes.
Frequently Asked Questions
What is the key structural difference between IGF-1 LR3 and IGF-1 DES?
IGF-1 LR3 has a 13-amino acid N-terminal extension plus an arginine substitution at position 3, totaling 83 amino acids. IGF-1 DES has the first three N-terminal amino acids removed, resulting in 67 amino acids. Both modifications reduce binding protein affinity.
How do their half-lives differ for research applications?
IGF-1 LR3 has a significantly extended half-life of approximately 20-30 hours due to reduced binding protein interaction. IGF-1 DES has a much shorter half-life of approximately 20-30 minutes, making it suitable for acute signaling studies.
Which variant is better for prolonged pathway studies?
IGF-1 LR3 is preferred for extended pathway studies due to its longer half-life and sustained receptor activation. IGF-1 DES is better suited for studying rapid, acute IGF-1 receptor signaling dynamics.
What documentation standards should researchers expect?
Both variants should include HPLC purity analysis (≥98%), mass spectrometry identity verification, amino acid composition analysis, and endotoxin testing from qualified research peptide suppliers.
Are IGF-1 variants available for research in Canada?
Yes, both IGF-1 LR3 and IGF-1 DES are available as research peptides in Canada from qualified suppliers. Products are labeled for research use only with appropriate documentation for laboratory applications.
Explore Research-Grade Compounds
All products include third-party testing documentation, batch-specific Certificates of Analysis, and secure checkout. For research use only.
Research Use Only: Products are intended for laboratory and scientific research purposes only. Not for human or veterinary use. By purchasing, you confirm compliance with all applicable regulations.