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Epithalon (Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, derived from the pineal polypeptide preparation Epithalamin. It is studied in cell-culture and animal-model work for reported effects on telomerase expression and circadian melatonin signalling. For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
Product Specifications
- CAS Number: 307297-39-8
- Molecular Formula: C₁₄H₂₂N₄O₉
- Molecular Weight: 390.35 g/mol
- Sequence: Ala-Glu-Asp-Gly
- Purity: measured by HPLC-UV, see the certificate of analysis for this compound
- Form: Lyophilized powder
- Quantity: 10mg per vial
Research Summary
Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide derived from the naturally occurring polypeptide Epithalamin, which is produced in the pineal gland. It has been the subject of extensive research into telomerase activation and its potential effects on cellular aging processes.
In vitro studies have demonstrated that Epithalon can activate telomerase, the enzyme responsible for maintaining telomere length during cell division. Research published in peer-reviewed journals has shown that treatment with Epithalon increased telomerase activity in human somatic cells, which may contribute to extended replicative capacity of cell cultures.
Animal model studies have investigated Epithalon’s effects on pineal gland function and melatonin secretion patterns. Research in aged rodent models showed that Epithalon exposure was associated with restoration of evening melatonin peaks that had diminished with age, suggesting a role in circadian rhythm regulation at the glandular level.
Additional preclinical research has explored Epithalon’s effects on antioxidant enzyme activity, with studies reporting increased superoxide dismutase and glutathione peroxidase activity in treated tissue samples compared to controls.
Storage
Store lyophilized peptide at -20°C. Reconstituted solution should be stored at 2-8°C and used within 28 days. Avoid repeated freeze-thaw cycles.
For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.
Related Research Reading
Extended mechanistic coverage is available in Epithalon telomerase activation and pineal mechanisms. Third-party analytical documentation is published on the Certificates of Analysis page, and the full research compound catalogue lists currently available compounds.
Maple Research Labs supplies epithalon to research laboratories across Canada for in-vitro and animal model study applications.
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