NAD+

Product Specifications

• CAS Number: 53-84-9
• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.43 g/mol
• Purity: >99%+ (HPLC verified)
• Form: Lyophilized powder
• Quantity: 500mg per vial

Research Summary

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells that functions as a critical electron carrier in metabolic redox reactions. In-vitro studies have extensively characterized its role as a substrate in over 500 enzymatic reactions, including those catalyzed by the sirtuin family of NAD+-dependent deacetylases (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38/CD157 ectoenzymes. These enzyme families have been investigated for their roles in DNA repair signaling, epigenetic regulation, and cellular stress response pathways in cell culture models.

In animal models, NAD+ metabolism has been studied in the context of age-related decline in intracellular NAD+ levels and its effects on mitochondrial function, genomic stability, and metabolic pathway regulation. Preclinical research has examined the compound’s influence on sirtuin-mediated deacetylation of transcription factors including PGC-1alpha, FOXO, and p53 in rodent tissue models. Researchers have also investigated NAD+ in relation to circadian rhythm signaling, where it serves as a substrate for the SIRT1-mediated regulation of CLOCK-BMAL1 transcriptional activity.

NAD+ serves as a fundamental research tool in cellular metabolism, aging biology, and enzymology studies. Its central role in energy metabolism, redox biology, and cell signaling makes it indispensable for in-vitro investigations across bioenergetics, epigenetics, and related research disciplines.

Storage

Store lyophilized peptide at -20°C. Reconstituted solution should be stored at 2-8°C and used within 28 days. Avoid repeated freeze-thaw cycles.

Shipping

Ships same-day from our Canadian facility. All orders include temperature-controlled packaging.

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Related Research Articles

Learn more about this compound through our peer-reviewed research summaries:

• NAD+ vs Glutathione: Cellular Research Comparison
• NAD+ and Longevity Peptides Research