SS-31 (Elamipretide)

Product Specifications

• CAS Number: 736992-21-5
• Molecular Formula: C₃₂H₄₉N₅O₅
• Molecular Weight: 587.76 g/mol
• Purity: measured by HPLC-UV, see the certificate of analysis for this compound
• Form: Lyophilized powder
• Quantity: 10mg per vial

Research Summary

SS-31 (Elamipretide) is a mitochondria-targeting tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂. Its unique alternating aromatic-cationic motif enables selective accumulation in the inner mitochondrial membrane, where it has been investigated for its interaction with cardiolipin. Cardiolipin is a phospholipid critical for electron transport chain (ETC) complex organization, and preclinical research suggests SS-31 stabilizes cardiolipin-dependent cristae structure and optimizes electron transfer efficiency.

In animal models of ischemia-reperfusion injury, SS-31 has been studied for its effects on mitochondrial reactive oxygen species (ROS) production, cytochrome c release, and mitochondrial membrane potential. In-vitro findings indicate that SS-31 reduces mitochondrial superoxide generation without acting as a direct free radical scavenger, instead modulating the efficiency of electron flow through Complex III and Complex IV. Research in rodent models has also examined its influence on ATP synthesis rates and mitochondrial bioenergetics under metabolic stress conditions.

Preclinical investigations in aged animal models have explored the relationship between SS-31 and age-related mitochondrial dysfunction, including studies measuring skeletal muscle energetics, cardiac function parameters, and renal mitochondrial morphology. Its favorable cell permeability and mitochondrial concentration properties have been characterized in pharmacokinetic studies across multiple species. Chavez and colleagues (PNAS, 2020) mapped its interaction landscape to complexes I, III and IV and to ATP synthase, and Chiao and colleagues (eLife, 2020) reported reversal of diastolic dysfunction with normalised proton leak in aged mice. Full coverage is in SS-31 cardiolipin-targeted mitochondrial research.

Storage

Store lyophilized peptide at -20°C. Reconstituted solution should be stored at 2-8°C and used within 28 days. Avoid repeated freeze-thaw cycles.

Shipping

Ships same-day from our facility in Canada. All orders include temperature-controlled packaging.

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Related Research Articles

Learn more about this compound through our peer-reviewed research summaries:

• NAD+ and Longevity Peptides Research
• NAD+ vs SS-31: Mitochondrial Research Comparison
• MOTS-c Mitochondrial-Derived Peptide Research
• Certificates of Analysis and Documentation

Related catalogue compounds: NAD+ and MOTS-c.